Neu5Ac-2Galβ1-3Glc-oxazoline- (2)

Neu5Ac-2Galβ1-3Glc-oxazoline- (2) Me (Compound G12) is a disaccharide linker. Neu5Ac-2Galβ1-3Glc-oxazoline- (2) Me can be efficiently recognized by the endo-glycosidase Endo-S2 and can be directedly transferred to the conserved N-glycosylation site (Asn297 position) of the antibody's Fc domain through enzymatic catalytic reactions, thereby achieving site-specific modification of the antibody. Neu5Ac-2Galβ1-3Glc-oxazoline- (2) Me can be used for for the synthesis of antibody-conjugated drugs (ADCs) [1].

2823367-76-4

12352005

ADC Linker

Antibody-drug Conjugate/ADC Related

Cancer

OC[C@@H](O[C@@]1([H])[C@@](N=C(O1)C)([H])[C@H]2O)[C@H]2O[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3CO[C@]4(O[C@@]([C@@H]([C@H](C4)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O

C25H40N2O18

656.59

[1]Wei Huang, et al. Disaccharide linker, disaccharide-small molecule drug conjugate and sugar chain fixed-point antibody-drug conjugate, and preparation method therefor and use thereof. WO2022174834A1. 2023-8-22

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180467/

ADC Related

No Development Reported