NEUCRIN Antilichaam

NEUCRIN Antibody: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.

374946

Q8NBI3

BAG80561

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

NEUCRIN Antibody is affinity chromatography purified via peptide column.

Cat. No. 1473 - Rat Cerebellum Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%), Bovine: (100%)

NEUCRIN Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NEUCRIN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.

DRAXIN

Chromosome 1 open reading frame 187

Homo sapiens

Islam SM, Shinmyo Y, Okafuji T, et al. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science 2009; 323:388-93.

Miyake A, Takahashi Y, Miwa H, et al. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Biochem. Biophys. Res. Commun. 2009; 390:1051-5.

Ahmed G, Shinmyo Y, Naser IB, et al. Olfactory bulb axonal outgrowth is inhibited by draxin. Biochem. Biophys. Res. Commun. 2010; 398:730-4.

NEUCRIN Antibody: UNQ3119, neucrin, AGPA3119, C1orf187, PSEC0258, UNQ3119/PRO10268, Draxin, Dorsal inhibitory axon guidance protein

ELISA, WB, IHC-P, IF

86990448

Liquid