Neuropiline-1-eiwit, menselijk, recombinant (aa 22-644, Avi & his), biotinyleerd
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors.
Ice Packs
-20°C
Beschrijving
Neuropiline-1-eiwit, menselijk, recombinant (aa 22-644, Avi & his), biotinyleerd Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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