Neurotrypsine Antilichaam

Neurotrypsin Antibody: Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.

8492

P56730

CAA04816

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Neurotrypsin Antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

Neurotrypsin Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Neurotrypsin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PRSS12

Cat. No. 10-301 - Human Brain Tissue Slide

Protease, serine, 12 (neurotrypsin, motopsin)

Homo sapiens

Gschwend TP, Krueger SR, Kozlov SV, et al. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol. Cell. Neurosci.1997; 9:207-19.

Molinari F, Rio M, Meskanaite V, et al. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science2002; 1779-81.

Mitsui S, Yamaguchi N, Osako Y, et al. Enzymatic properties and localization of motopsin (PRSS12), a protease who absence causes mental retardation. Brain Res.2007; 1136:1-12.

Neurotrypsin Antibody: MRT1, BSSP3, BSSP-3, Neurotrypsin, Leydin

ELISA, WB, IHC-P, IF

2661424

Liquid