NF2 Antilichaam, KO gevalideerd

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

4771

P35240

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 477-576 of human NF2 (NP_000259.1) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Affinity purification

A549

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 80kDa

IgG

NF2

A431

HeLa

SKOV3

Mouse kidney

Mouse heart

Neurofibromin 2 (merlin)

Homo sapiens

NF2, ACN, BANF, Moesin-ezrin-radixin like, Neurofibromin 2 (merlin), Neurofibromin-2, SCH, Merlin, Schwannomerlin, Schwannomin

WB, IHC

Liquid