NFE2 Antibody - N-terminal regio : HRP (ARP31217_P050-HRP)

Nuclear factor (erythroid-derived 2), 45kDa

P45, NF-E2

4778

Q16621

NP_006154

Human, Mouse, Rat, Cow, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the N terminal region of human NFE2

NFE2 is a component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. NFE2 binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR) . This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. NFE2 is requires MAFK or other small MAF proteins for binding to the NF-E2 motif. NFE2 may play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

BTRC; NFE2L3; NFE2L2; NFE2; ATF4; Dlg4; TXN; ITCH; Yap1; Nedd4; WWP1; MAPK8; KAT2B; SCAND1; SSX5; HMGN1; ELF5; PHYHIP; MAFF; MAFG; PEX14; MAFK; CREBBP

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 92%; Guinea Pig: 87%; Horse: 87%; Human: 100%; Mouse: 77%; Rat: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

41kDa

Wet Ice

373

NFE2

NFE2

Rabbit

Transcription factor NF-E2 45 kDa subunit

NM_006163

MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEP