NFkB p100 / p52 (Ab 866) Antilichaam

NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κ -B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κ -B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.

4791

Q00653

NP_001070961.1

Human, Mouse, Rat

NFkB-p100/p52 (Ab-866) antibody was raised against a peptide sequence around aa.864~868 (E-D-S-A-Y) derived from Human NFκ B-p100/p52.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

120 kDa

This antibody detects endogenous level of total NFκ B-p100/p52 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

NFKB2

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Homo sapiens

Qu Z, et al. (2004) J Biol Chem. 279 (43) : 44563-44572. Xiao G, et al. (2001) Mol Cell. 7 (2) : 401-409. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.

P52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, EIF4F, EIF4G, EIF4GI, DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Lyt10, NFKB2

WB, IHC, IF

117320540

Liquid