NFkB p100 / p52 (Ab 872) Antilichaam

NF-κ -B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ -B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

4791

Q00653

NP_001070961.1

Human, Mouse

NFkB-p100/p52 (Ab-872) antibody was raised against a peptide sequence around aa.870~874 (S-Q-S-V-E) derived from Human NFκ B-p100/p52.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

52, 120 kDa

This antibody detects endogenous level of total NFκ B-p100/p52 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

NFKB2

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Homo sapiens

Shin HM, et al. (2006) EMBO J; 25 (1) : 129-138. Li Q, et al. (2005) Proc Natl Acad Sci USA; 102 (35) : 12425-12430. Chen C, et al. (2000) Mol Cell Biol; 20 (8) : 2687-2695.

P52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, FLK1, VEGFR2, DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Lyt10, NFKB2

WB, IHC, IF

117320540

Liquid