NFkB p105 / p50 (Ab 932) Antilichaam

NF-κ -B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ -B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

4790

P19838

NP_001158884.1

Human, Mouse, Rat

NFkB-p105/p50 (Ab-932) antibody was raised against a peptide sequence around aa.930~934 (E-T-S-F-R) derived from Human NFκ B-p105.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

50, 120 kDa

This antibody detects endogenous level of total NFκ B-p105/p50 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

NFKB1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Homo sapiens

Soren Beinke et al. (2004) Biochem J. 382 (Pt 2) : 393–409. Vigo Heissmeyer1, et al. (1999) The EMBO Journal 18: 4766–4778, F Chen, et al. (2006) Cell Death and Differentiation 13: 1835–1838. Kris A. Steinbrecher, et al. (2005) Mol Cell Biol. 25 (19) : 8444–8455.

P50, KBF1, p105, EBP-1, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B, PRMT4, DNA-binding factor KBF1, NF-kappa-B1 p84/NF-kappa-B1 p98, NFKB1, NFkB-p50

WB, IHC

259155302

Liquid