NGFR-antilichaam

NGFR Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κ B and various mitogen-activated protein kinases. Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family. Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4. NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins. Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR.

4804

P08138

NP_002498

Human, Mouse

NGFR antibody was raised against purified recombinant human NGFR.

Unconjugated

Primary Antibodies

Growth Factors

NGFR Antibody is Protein A purified.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

NGFR Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NGFR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NGFR

Cat. No. 17-208 - A-20 Cell Slide

Nerve growth factor receptor (TNFR superfamily, member 16)

Homo sapiens

Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.

Johnson D, Lanahon A, Buck CR, et al. Expression and structure of the human NGF receptor. Cell 1986; 47:545-54.

Gentry JJ, Barker, PA, and Carter BD. The p75 neuro-trophin receptor: multiple interactors and numerous functions. Prog. Brain Res. 2004;146:25-39.

Nykjaer A, Willnow TE, and Petersen CM. p75NTR - live or let die. Curr. Opin. Neurobio. 2005; 15:49-57.

NGFR Antibody: CD271, p75NTR, TNFRSF16, p75 (NTR), Gp80-LNGFR, Tumor necrosis factor receptor superfamily member 16, NGF receptor

ELISA, WB, ICC, IF

4505393

Liquid