NH2-PEG4-Val-Cit-PAB-OH
Gecertificeerd

NH2-PEG4-Val-Cit-PAB-OH

Catalog #: TYD-02059-01
Maat: 10 mg

Kwaliteit

ISO Gecertificeerd

Levering

24-48 uur

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Gratis verzending vanaf €100
Technische Documentatie

Technische Specificaties

CAS Number

2055024-61-6

Target

ADC Linker

Related Pathways

Antibody-drug Conjugate/ADC Related

Bioactivity

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker that features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB component is suitable for attaching reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine is versatile for reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, or other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular cathepsins, allowing efficient payload delivery via an elimination mechanism through the PAB structure.

Smiles

N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCN)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C1=CC=C(CO)C=C1

Molecular Formula

C29H50N6O9

Molecular Weight

626.742

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Beschrijving

NH2-PEG4-Val-Cit-PAB-OH Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.

Specificaties

ProductnaamNH2-PEG4-Val-Cit-PAB-OH
Categorie
Beschikbare grootte10 mg
CatalogusnummerTYD-02059-01