Nhe-1 Antilichaam

Nhe-1 Antibody: The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension.

6548

P19634

P19634

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Nhe-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1465 - Rat Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (95%), Pig: (95%), Bovine: (95%)

Nhe-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Nhe-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of Nhe-1 are known to exist.

SLC9A1

Cat. No. 10-301 - Human Brain Tissue Slide

Solute carrier family 9 (sodium/hydrogen exchanger), member 1

Homo sapiens

Mendoza SA. The Na+-H+ antiport is a mediator of cell proliferation. Acta Paediatr. Scand. 1987; 76:545-7.

Denker SP, Huang DC, Orlowski J, et al. Direct binding of the NA—H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H (+) translocation. Mol. Cell. 2000; 6:1425-36.

Cingolani HE, Rebolledo OR, Portiansky EL, et al. Regression of hypertensive myocardial fibrosis by NA (+) /H (+) exchange inhibition. Hypertension 2003; 41:373-7.

Nhe-1 Antibody: APNH, NHE1, NHE-1, APNH1, APNH

ELISA, WB, IHC-P, IF

127809

Liquid