NIBRIN Antilichaam

NIBRIN Antibody: NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.

4683

O60934

NP_002476

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

NIBRIN Antibody is affinity chromatography purified via peptide column.

Cat. No. 1462 - Rat Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (85%)

NIBRIN Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NIBRIN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three alternatively spliced transcript isoforms of NIBRIN are known to exist.

NBN

Cat. No. 10-101 - Human Lung Tissue Slide

Nibrin

Homo sapiens

Carney JP, Maser RS, Olivares H, et al. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 1998; 93:477-86

Marcelain K, De La Torre C, Gonzalez P, et al. Roles of nibrin and AtM/ATR kinases on the G2 checkpoint under endogenous or radio-induced DNA damage. Biol. Res. 2005; 38:179-85.

Varon R, Vissinga C, Platzer M, et al. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 1998; 93:467-76.

Heikkinen K, Karppinen SM, Soini Y. et al. Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. J. Med. Genet. 2003; 40:E131.

NIBRIN Antibody: ATV, NBS, P95, NBS1, AT-V1, AT-V2, Nibrin, Cell cycle regulatory protein p95

ELISA, WB, IHC-P, IF

33356172

Liquid