Nicotinamide N-oxide-d4

Nicotinamide N-oxide-d4 is the deuterium labeled Nicotinamide N-oxide. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

1246817-64-0

12352005

CXCR; Drug Metabolite; Endogenous Metabolite; Isotope-Labeled Compounds; Oxidative Phosphorylation

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Inflammation/Immunology

O=C(C1=C([2H])[N+]([O-])=C([2H])C([2H])=C1[2H])N

C6H2D4N2O2

142.15

[1]Real AM, et al. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes. Drug Metab Dispos. 2013 Mar;41 (3) :550-3.|[2]Cutshall NS, et al. Nicotinamide N-oxides as CXCR2 antagonists. Bioorg Med Chem Lett. 2001 Jul 23;11 (14) :1951-4.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W701397/

Isotope-Labeled Compounds

No Development Reported