Nicotinezuur riboside-d4

Nicotinic acid riboside-d4 is the deuterium labeled Nicotinic acid riboside. Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2].

12352005

Endogenous Metabolite; Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others

Cancer

O[C@@H]1[C@@H]([C@H](O[C@H]1[N+]2=C(C(C([O-])=O)=C(C([2H])=C2[2H])[2H])[2H])CO)O

C11H9D4NO6

259.25

[1]Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842.|[2]Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [published correction appears in J Biol Chem. 2010 Jan 29;285 (5) :3524]. J Biol Chem. 2009;284 (50) :34861-34869.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W742088/

Isotope-Labeled Compounds

No Development Reported