Niemann Pick C1/NPC1 Proteïne, Humaan, Recombinant (His & FLAG)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP) -mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick type C1. NPC1 localizes predominantly to late endosomes and has a dileucine motif located within a small cytoplasmic tail thought to target the protein to this location. Niemann-Pick disease type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. On the cellular level, NPC1 mutations lead to an accumulation of cholesterol and gangliosides.
Ice Packs
-20°C
Beschrijving
Niemann Pick C1/NPC1 Proteïne, Humaan, Recombinant (His & FLAG) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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