NIK Antilichaam

NIK Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα , LPS and mitogens. A serine/threonine protein kinase which mediates NF-κ B activation by IL-1, TNFα and CD95 was identified recently and designated NIK (for NF-κ B inducing kinase) . NIK is an activator of Iκ B kinase alpha and beta (IKKα and IKKβ ) . Therefore, NIK is a key molecule in the NF-κ B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

9020

Q99558

Q99558

Human

Unconjugated

Primary Antibodies

Signal Transduction

NIK Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Mouse: (94%)

NIK Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NIK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Predicted: 104 kDa

IgG

MAP3K14

Mitogen-activated protein kinase kinase kinase 14

Homo sapiens

Malinin NL, Boldin MP, Kovalenko AV, et al. MAP3K-related kinase involved in NF-κ B induction by TNF, CD95 and IL-1. Nature 1997; 385:540-4.

Regnier CH, Song HY, Gao X, et al. Identification and characterization of an Iκ B kinase. Cell 1997; 90:373-83.

Woronicz JD, Gao X, Cao Z, et al. Iκ B kinase-β : NF-κ B activation and complex formation with Iκ B kinase-α and NIK. Science 1997; 278:866-9.

Ling L, Cao Z, and Goeddel D. NF-κ B-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 1998; 95:3792-7.

NIK Antibody: HS, NIK, HSNIK, FTDCR1B, Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK

ELISA, WB, IF, ICC

92090612

Liquid