Nimesulide-13C6

Nimesulide-13C6 (R805-13C6) is 13C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM) . Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

R805-13C6

12352005

COX; Isotope-Labeled Compounds

Immunology/Inflammation; Others

COVID-19-immunoregulation

Inflammation/Immunology; Cancer

CS(=O)(NC1=CC=C(C=C1O[13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)[N+]([O-])=O)=O

C7 13C6H12N2O5S

314.27

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45 (10) :1096-8.|[3]Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543 (1-3) :181-9.|[4]Genç S, et al. The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. Clin Exp Med. 2007 Mar;7 (1) :6-10.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0363S1/

Isotope-Labeled Compounds

No Development Reported