NINJ1 Antilichaam

Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons (1,2), suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality (3) .

4814

Q92982

NP_004139

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience, Apoptosis

NINJ1 antibody is affinity chromatography purified via peptide column.

1 mg/mL

NINJ1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NINJ1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

NINJ1 antibody is human, mouse and rat reactive.

NINJ1

Ninjurin 1

Homo sapiens

Araki T and Milbrandt J. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. Neuron 1996; 17:353-61.

Araki T, Zimonjic DB, Popescu NC, et al. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J. Biol. Chem. 1997; 212:21373-80.

Cho SJ, Rossi A, Jung YS, et al. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, sensecence, and radiation-induced mortality. Proc. Natl. Acad. Sci. USA 2013; 110:9362-7.

NINJ1 Antibody: NIN1, NINJURIN, Ninjurin-1, Nerve injury-induced protein 1

ELISA, IHC-P, IF

148922911

Liquid