Nipecotisch zuur (standaard)

Nipecotic acid (Standard) is the analytical standard of Nipecotic acid. This product is intended for research and analytical applications. Nipecotic acid ((±) -β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].

498-95-3

12352100

GABA Receptor; Reference Standards

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Neurological Disease

O=C(C1CNCCC1)O

C6H11NO2

129.16

[1]Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA (A) -like ion channels. Br J Pharmacol. 2001 Jul;133 (5) :673-8.|[2]Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg) . 2021 Feb;71 (2) :94-103.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-69359R/

Reference Standards