Nitromantine

Nitromemantine is a nitrate derivative of Memantine and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke[1].

765890-91-3

12352211

Drug Derivative; iGluR

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Cardiovascular Disease; Neurological Disease

CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1

C14H24N2O3

268.35

[1]Takahashi H, et al. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci Rep. 2015 Oct 19;5:14781.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180370/

Reference compound1

No Development Reported