NK224

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) [1].

12352209

PD-1/PD-L1

Immunology/Inflammation

Cancer

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C104H145N25O29S

2241.48

[1]Zhao L, et al. 68Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study. Clin Cancer Res. 2025 Jul 15;31 (14) :2989-3001.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10978/

Peptides

No Development Reported