NK3R Antilichaam

NK3R Antibody: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

6870

P29371

P29371

Human, Mouse

Unconjugated

Primary Antibodies

Neuroscience

NK3R Antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Rabbit: (94%), Guinea pig: (83%)

NK3R Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NK3R antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

NK3R antibody does not recognize NK1R or NK2R.

TACR3

Cat. No. 1303 - Human Brain Tissue Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

Tachykinin receptor 3

Homo sapiens

Maggi CA. The mammalian tachykinin receptors. Gen. Pharmacol. 1995; 26:911-44.

Ding Y-Q, Shi J, Su L-Y, et al. Receptor (NK3) -containing neurons in the paraventricular and supraoptic nuclei of the rat hypothalamus synthesize vasopressin and express fos following intravenous injection of hypotonic saline. Neurosci. 1999; 91:1077-85.

Nakajima Y, Tsuchida K, Negishi M, et al. Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells. J. Biol. Chem. 1992; 267:2437-42.

Haley GE and Flynn FW. Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge. Am. J. Regul. Integr. Comp. Physiol. 2007; 293:R931-7.

NK3R Antibody: NKR, HH11, NK3R, NK-3R, TAC3RL, TAC3R, Neuromedin-K receptor, NK-3 receptor, NKR

ELISA, WB, IHC-P, IF

128364

Liquid