NKp46/NCR1, menselijk (gebiotinyleerd, HEK293, Fc-Avi)

NKp46/NCR1 Protein is a major NK cell-activating receptor that is involved in the elimination of target cells and recognizing a wide range of tumors, viruses, and bacteria. NKp46 forms microclusters structures at the immune synapse between NK cells and target cells. Over-expression of human NKp46 is correlated with increased accumulation of F-actin mesh at the immune synapse. NKp46 signaling directly regulates the NK lytic immune synapse from early formation to late function[1][2][3]. NKp46/NCR1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

NKp46/NCR1 Protein, Human (Biotinylated, HEK293, Fc-Avi), Human, HEK293

12352202

9437 (Gene_ID) AAH64806 (Q22-N254) (Accession)

60-65 kDa

[1]Uzi Hadad, et al. NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization. Front Immunol. 2015 Sep 25:6:495.|[2]S Sivori, et al. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells. Eur J Immunol. 1999 May;29 (5) :1656-66.|[3]Alexander David Barrow, et al. The Natural Cytotoxicity Receptors in Health and Disease. Front Immunol. 2019 May 7:10:909.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins