NLGN2 Antilichaam

Neuroligin 2 (NLGN2) is a member of a family of neuronal cell surface proteins that localize to the post-synaptic membrane (1,2) . Neuroligins are thought to act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses (2) . NLGN2 has been shown to control perisomatic inhibitory synapse maturation together with gephyrin and collybistin, thereby regulating GABA receptor clustering on neurons (3,4) . NLGN2 also exhibits differential functions at different types of inhibitory synapses on the same postsynaptic neuron (5) .

57555

Q8NFZ4

NP_065846

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

NLGN2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

NLGN2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NLGN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.

NLGN2

Neuroligin 2

Homo sapiens

Ichtchenko K, Nguyen T, and Sudhof TC. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J. Biol. Chem. 1996; 271:2676-82.

Bang ML and Owczarek S. A matter of balance: role of neurexin and neuroligin at the synapse. Neurochem. Res. 2013; 38:1174-89.

Poulopoulos A, Aramuni G, Meyer G, et al. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitiory synapses through gephyrin and collybistin. Neuron 2009; 63:628-42.

Jedlicka P, Hoon M, Poulopoulos T, et al. Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb. Cortex 2011; 21:357-67.

Neuroligin 2

ELISA, WB, IHC-P, IF

30840978

Liquid