NMDAR1 (fosfo Ser890) Antilichaam

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD) . NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

2902

Q05586

NP_000823.4

Human, Mouse, Rat

NMDAR1 (phospho Ser890) antibody was raised against a peptide sequence around phosphorylation site of serine890 (A-S-S (p) -F-K) derived from Human NMDAR1 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

105 kDa

IgG

The antibody detects endogenous level of NMDAR1 only when phosphorylated at serine 890.

Western Blot: 1:500~1:1000

GRIN1

Glutamate receptor, ionotropic, N-methyl D-aspartate 1

Homo sapiens

Xu M, Smothers CT, Woodward JJ (2011) Alcohol 45, 373-80. Kong M, Ba M, Song L, Liu Z (2009) Neurochem Res 34, 1513-21 . Jackson MF, et al. (2006) J Neurochem 96, 1509-18.

GLURZ1, GRIN1, N-methyl-D-aspartate receptor, NMZ1, NMDZ1

WB

11496971

Liquid