NN1213

NN1213 (Peptide 21), a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with an EC50 of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 significantly reduces appetite in rat and dog models. NN1213 can be used for antiobesity research[1].

12352209

Amylin Receptor

GPCR/G Protein

Metabolic Disease

O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CO)C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@H]7[C@H](O)C)=O)=O)=O)=O)[C@@H](N)CCCCNC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O

C198H316N56O63S2

4553.10

[1]Dahl K, et al. NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. J Med Chem. 2024 Jul 25;67 (14) :11688-11700. doi: 10.1021/acs.jmedchem.4c00022. Epub 2024 Jul 3. Erratum in: J Med Chem. 2024 Dec 26;67 (24) :22342.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11245/

Peptides

No Development Reported