NN1213 (acetaat)

NN1213 acetate (Peptide 21), a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with an EC50 of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 acetate significantly reduces appetite in rat and dog models. NN1213 acetate can be used for antiobesity research[1].

12352209

Amylin Receptor

GPCR/G Protein

Metabolism-protein/nucleotide metabolism

Metabolic Disease

99.65

DMSO : 100 mg/mL (ultrasonic)

CC(O)=O.O=C([C@H](CCCCNC(CC[C@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)C(O)=O)=O)N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=C(O)C=C4)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CO)=O)=O)C(C)C)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)CO)=O)CCC3)=O)[C@H](CC)C)=O)C)=O)=O)CC5=CC=CC=C5)=O)CC(N)=O)=O)CCC2)=O)CO)=O)CO)=O)CC6=CNC=N6)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC7=CC=CC=C7)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)O)=O)C)=O.[x]

C198H316N56O63S2.xC2H4O2

4553.10 (free base)

[1]Dahl K, et al. NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. J Med Chem. 2024 Jul 25;67 (14) :11688-11700. doi: 10.1021/acs.jmedchem.4c00022. Epub 2024 Jul 3. Erratum in: J Med Chem. 2024 Dec 26;67 (24) :22342.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P11245A/NN1213-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported