NNC0165-1273 (TFA)

NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273. NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research[1].

12352209

Neuropeptide Y Receptor

GPCR/G Protein; Neuronal Signaling

Metabolic Disease

97.79

NC(NCCC[C@@H](CC(N[C@@H](CC1=CC=C(C=C1)O)C(N)=O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=CC=CC=C32)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(C=C4)O)NC([C@H](CC5=CNC=N5)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](C)NC([C@H](CC6=CC=C(C=C6)O)NC([C@H](CC7=CC=C(C=C7)O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H]8CCCN8C([C@H](CO)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@@H]9CCCN9C([C@H](C)NC([C@H](CCC(O)=O)NC([C@@H]%10CCCN%10C([C@H](CCCCN)NC([C@H]([C@@H](C)CC)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=N.OC(C(F)(F)F)=O.[x]

C186H280N54O54·xC2HF3O2

4136.54 (free base)

[1]Jones ES, et al. Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice. Endocrinology. 2019 Nov 1;160 (11) :2737-2747.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P11291A/NNC0165-1273-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported