Nocarnikkelamide B

Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch[1].

12352005

Myosin; ROCK

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Cancer-Kinase/protease

Others

CC(C)C[C@@H](NC(CNC([C@H]1N(C([C@H](N)CC2=CC=CC=C2)=O)C[C@H](O)C1)=O)=O)C(N3C[C@H](O)C[C@H]3C(NCC(O)=O)=O)=O

C29H42N6O9

618.68

[1]Bui TTM, Ko H, Um S, Jeong H, Kang SW, Kim H, Song DG, Jung SH, Moon K. Discovery of Dual ROCK1/2 Inhibitors from Nocardiopsis sp. under Metal Stress. ACS Chem Biol. 2025 Feb 21;20 (2) :432-441

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15301/

Natural Products

No Development Reported

ROCK1; ROCK2