NOD1 Antilichaam

NOD1 Antibody: NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-κ B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.

10392

Q9Y239

Q9Y239

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity, Inflammasomes

NOD1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

NOD1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NOD1

Nucleotide-binding oligomerization domain containing 1

Homo sapiens

Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci.2006; 1072:19-27.

Inohara N, Koseki T, del Peso L, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem.1999; 274:14560-7.

Chamaillard M, Hashimoto M, Horie Y, et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol.2003; 4:702-7.

NOD1 Antibody: CARD4, NLRC1, CLR7.1, Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1

ELISA, WB

20137579

Liquid