NOD2 Antilichaam

NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD) . A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κ B, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.

64127

Q9HC29

Q9HC29

Human

Unconjugated

Primary Antibodies

Apoptosis, Inflammasomes

NOD2 Antibody is immunoaffinity chromatography purified IgG.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

NOD2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of NOD2 are known to exist; this antibody will only detect the longest isoform. NOD2 has no cross-reaction with NOD1.

NOD2

Cat. No. 1369 - Human Lymph node Tissue Lysate

Cat. No. 17-005 - Jurkat Cell Slide

Nucleotide-binding oligomerization domain containing 2

Homo sapiens

Inohara N, Koseki T, del Peso L, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κ B. J. Biol. Chem. 1999; 274:14560-7.

Ogura Y, Inohara N, Benito A, et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κ B. J. Biol. Chem. 2001; 276:4812-8.

Hugot JP, Chamaillard M, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411:599-603.

Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411:603-6.

NOD2 Antibody: CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1, Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15

ELISA, WB, ICC, IF

20137973

Liquid