NOD3 Antilichaam

NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.

197358

Q7RTR2

EAW85351

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

NOD3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NLRC3

Cat. No. 17-005 - Jurkat Cell Slide

NLR family, CARD domain containing 3

Homo sapiens

Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci.2006; 1072:19-27.

Conti BJ, Davis BK, Zhang J, et al. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J. Biol. Chem.2005; 280:18375-85.

NOD3 Antibody: NOD3, CLR16.2, NOD3, Protein NLRC3, CARD15-like protein

ELISA, WB, IF

119605757

Liquid