NOD4 Antilichaam

NOD4 Antibody: NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-κ B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.

84166

Q86WI3

NP_115582

Human, Mouse

Unconjugated

Primary Antibodies

Innate Immunity

NOD4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

NOD4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOD4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

205 kDa

IgG

NOD4 antibody is predicted to not cross-react with other members of the NOD family of proteins.

NLRC5

Cat. No. 17-001 - HeLa Cell Slide

NLR family, CARD domain containing 5

Homo sapiens

Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci. 2006; 1072:19-27.

Benko S, Magalhaes JG, Philpott DJ, et al. NLRC5 limits the activation of inflammatory pathways. J. Immunol. 2010; 185:1681-91.

Meissner TB, Li A, Biswas A, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. USA 2010; 107:13794-9.

Cui J, Zhu L, Xia X, et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 2010; 141:483-96.

NOD4 Antibody: NOD4, NOD27, CLR16.1, NOD4, Protein NLRC5, Nucleotide-binding oligomerization domain protein 27

ELISA, WB, ICC, IF

116268109

Liquid