NOD5 Antilichaam

NOD5 Antibody: NOD5, also known as NLRX1, is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD5 localizes to the mitochondrial outer membrane and interacts with the virus-induced signaling adapter protein VISA. Unlike a subset of NOD-like receptors (NLRs) such as NOD1 and NOD2 which trigger pro-inflammatory cascades, and other NLRs that induce the caspase 1 inflammasome in response to immune challenges, NOD5 amplifies NF-κ B and JNK pathways by inducing reactive oxygen species production.

79671

Q86UT6

NP_078894

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

NOD5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1466 - Rat Spleen Tissue Lysate

1 mg/mL

NOD5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOD5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NLRX1

NLR family member X1

Homo sapiens

Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci.2006; 1072:19-27.

Moore CB, Bergstralh DT, Duncan JA, et al. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature2008; 451:573-7.

Tattoli I, Carneiro LA, Jehanno M, et al. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kB and JNK pathways by inducing reactive oxygen species. EMBO Reports2008; 9:293-300.

NOD5 Antibody: NOD5, NOD9, NOD26, DLNB26, CLR11.3, NOD5, NLR family member X1, Nucleotide-binding oligomerization domain protein 26

ELISA, WB, IHC-P, IF

25777608

Liquid