Nogo B receptor (NUS1) (NM 138459) Humaan Recombinant Proteïne

This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]

Purified recombinant protein of Human nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) (NUS1), Arg38-Asp116, with N-terminal His-Trx tag, expressed in E. coli, 50ug

C6orf68; CDG1AA; MGC:7199; MRD55; NgBR; TANGO14

116150

Q96E22

NM_138459

6q22.1

E. coli

N-His-Trx

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

29.2 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

NUS1

Human

NP_612468

https://www.ncbi.nlm.nih.gov/gene/116150

https://www.uniprot.org/uniprot/Q96E22

https://www.ncbi.nlm.nih.gov/nuccore/NM_138459

https://www.ncbi.nlm.nih.gov/nuccore/NP_612468