Norfenfluramine (hydrochloride)

Norfenfluramine hydrochloride ((±) -Norfenfluramine hydrochloride) is the primary metabolite of Fenfluramine, formed through N-dealkylation of Fenfluramine. Norfenfluramine hydrochloride is also a potent anorexiant. Norfenfluramine hydrochloride can regulate serotonergic neurotransmission. In addition, Norfenfluramine hydrochloride exhibits sedative effects after acute administration[1][2].

673-18-7

(±) -Norfenfluramine (hydrochloride)

12352005

Drug Metabolite

Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Neurological Disease

NC(CC1=CC=CC(C(F)(F)F)=C1)C.Cl

C10H13ClF3N

239.67

[1]Martin P, et al. In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. Pharmacol Res Perspect. 2022 Jun;10 (3) :e00958.|[2]Goudie AJ, et al. Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: an evaluation of its role in the actions of fenfluramine. Psychopharmacologia. 1974;38 (1) :67-74.|[3]Rothman RB, Clark RD, Partilla JS, Baumann MH. (+) -Fenfluramine and its major metabolite, (+) -norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003;305 (3) :1191-1199.|[4]Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64 (6) :1673-1683.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W707158/

Reference compound1

No Development Reported