Norquetiapine (standaard)

Norquetiapine is an antidepressant and neuroprotective agent and is the active metabolic component of Quetiapine. Norquetiapine is also a partial 5-HT1A receptor agonist, and a presynaptic α2, 5-HT2C and 5-HT7 b> Receptor antagonist. Norquetiapine can also selectively inhibit norepinephrine transporter (NET), inhibit norepinephrine reuptake, and has potential inhibitory effects on bipolar depression, major depressive disorder, and generalized anxiety disorder. Norquetiapine demonstrated in vivo activity in forced swimming in mice and learned helplessness tests in rats[1][2].

5747-48-8

N-Desalkylquetiapine (Standard)

12352005

5-HT Receptor

GPCR/G Protein; Neuronal Signaling

Neurological Disease

C12=CC=CC=C1N=C(C3=CC=CC=C3S2)N4CCNCC4

C17H17N3S

295.41

[1]Kim DH, Park KS, Park SH, Hahn SJ, Choi JS. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Eur J Pharmacol. 2020 Oct 15;885:173532. |[2]Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173 (1) :155-66.|[3]Jean Jacques A, et al. Inhibition of HCN1 currents by norquetiapine, an active metabolite of the atypical anti-psychotic drug quetiapine. Front Pharmacol. 2024 Oct 7;15:1445509.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W052508R/

Reference Standards

No Development Reported