NOSTRIN Antilichaam

NOSTRIN. also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins which may function as the modulator of the subcellular localisation and activity of endothelial nitric oxide synthase (eNOS) (1,2) . It decreases NOS3 activity by inducing its translocation away from the plasma membrane (3) . NOSTRIN typically exists as a trimer and is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. NOSTRIN is necessary for proper vascular development in zebrafish and postnatal retinal angiogenesis in mice (4,5) .

115677

Q8IVI9

NP_443178

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

NOSTRIN antibody is affinity chromatography purified via peptide column.

Cat. No. 1221 - SW480 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

NOSTRIN antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOSTRIN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

NOSTRIN antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect all four isoforms.

NOSTRIN

Nitric oxide synthase trafficking

Homo sapiens

Zimmermann K, Opitz N, Dedio J, et al. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 2002; 99:17167-72.

Icking A, Matt S, Opitz N, et al. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J. Cell Sci. 2005; 118:5059-69.

Schilling K, Opitz N, Wiesenthal A, et al. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol. Biol. Cell 2006; 17:3870-80.

Icking A, Schilling K, Wiesenthal A, et al. FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. FEBS Lett. 2006; 580:223-8.

Nitric oxide synthase traffic inducer, eNOS-trafficking inducer, Nitric oxide synthase trafficker, BM247 homolog, DaIP2

ELISA, WB, IHC-P, IF

284172479

Liquid