NOTA-WL12
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
NOTA-WL12 is a conjugate of WL12 (peptide targeting PD-L1) and NOTA (HY-134418) (chelate). NOTA-WL12 shows high binding affinity to the PD-L1 (KD = 3.012 nM). NOTA-WL12 can be labeled with radioactive isotopes for tumor imaging[1].
2767203-39-2
12352209
Drug Derivative; PD-1/PD-L1
Immunology/Inflammation; Others
Cancer
CN1C2=CC=CC=C2C(C[C@H]3C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N4[C@](CCC4)([H])C(N[C@H](C(N[C@H](C(N5[C@](C[C@H](C5)O)([H])C(N[C@H](C(N[C@H](C(N3)=O)CO)=O)CC6=CNC7=CC=CC=C67)=O)=O)CC(C)C)=O)CC8=CN=CN8)=O)=O)CC(N)=O)=O)C)C)=O)CC9=CC=C(C=C9)O)=O)C(NCC(N)=O)=O)=O)CCCNC(NC%10=CC=C(CC(N%11CC(O)=O)CN(CCN(CC%11)CC(O)=O)CC(O)=O)C=C%10)=S)=O)CCCC)C)=O)CCCC)C)=O)=C1
C111H154N26O26S2
2332.70
[1]Jiang J, et al. Noninvasive evaluation of PD-L1 expression using Copper 64 labeled peptide WL12 by micro-PET imaging in Chinese hamster ovary cell tumor model. Bioorg Med Chem Lett. 2021 May 15;40:127901.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P3440A/
Peptides
No Development Reported
Beschrijving
NOTA-WL12 is a conjugate of WL12 (peptide targeting PD-L1) and NOTA (HY-134418) (chelate). NOTA-WL12 shows high binding affinity to the PD-L1 (KD = 3.012 nM). N
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