NOTCH1 Mouse Monoclonal Antibody [Kloon ID: LBI3E12]

Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development

Carrier-free (BSA/glycerol-free) Notch1 mouse monoclonal antibody, clone LBI3E12

AOS5; AOVD1; hN1; TAN1

Homo sapiens notch receptor 1 (NOTCH1), mRNA.

4851

P46531

Unconjugated

Dorso-ventral axis formation, Notch signaling pathway, Prion diseases

Dorso-ventral axis formation, Notch signaling pathway, Prion diseases

WB: 1:1000; IHC 1;50; RPPA 1:75; IF: 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

NOTCH1

https://www.ncbi.nlm.nih.gov/gene/?term=4851

https://www.uniprot.org/uniprot/P46531