NOTCH1 (NM 017617) Humaan Recombinant Proteïne

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]

Purified recombinant protein of Human notch 1 (NOTCH1), Ala2280-End, with N-terminal His tag, expressed in E. coli, 50ug

AOS5; AOVD1; hN1; TAN1

4851

P46531

NM_017617

9q34.3

E. coli

N-His

Dorso-ventral axis formation, Notch signaling pathway, Prion diseases

Dorso-ventral axis formation, Notch signaling pathway, Prion diseases

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway

29 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

NOTCH1

Human

NP_060087

https://www.ncbi.nlm.nih.gov/gene/4851

https://www.uniprot.org/uniprot/P46531

https://www.ncbi.nlm.nih.gov/nuccore/NM_017617

https://www.ncbi.nlm.nih.gov/nuccore/NP_060087