NOTCH3 Antilichaam

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) .

4854

Q9UM47

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 2200 to the C-terminus of human NOTCH3 (NP_000426.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience, Signal Transduction, Stem Cell, Transcription

Affinity purification

OVCAR2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 280kDa

IgG

WB: 1:500 - 1:2000

NOTCH3

Mouse ovary

Notch 3

Homo sapiens

NOTCH3, Notch homolog 3 (Drosophila), HGNC:7883, CADASIL, CASIL, Notch (Drosophila) homolog 3, Notch homolog 3, IMF2

WB

Liquid