NOX1 Antilichaam

Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress (1) . NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox (1) . Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv (2) . NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain (1-3) . NOX1 have the potential to be effective treatments for a range of ischemic diseases (4) .

27035

Q9Y5S8

NP_008983

Human

Unconjugated

Primary Antibodies

Immunology

NOX1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (93%), Mouse: (85%)

NOX1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

NOX1 antibody is human specific.

NOX1

Cat. No. 10-401 - Human Kidney Tissue Slide

NADPH oxidase 1

Homo sapiens

Helmcke I, Heumuller S, Tikkanen R, et al. Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid. Redox Signal. 2009; 11:1279-87.

Piccoli C, D'Aprile A, Ripoli M, et al. Bone-marrow derived hematopoietic stem/progenitor cells express multiple isoforms of NADPH oxidase and produce constitutively reactive oxygen species. Biochem. Biophys. Res. Commun. 2007; 353:965-72.

Lee JG, Lim EJ, Park DW, et al. A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation. Cell Signal. 2008; 20:2266-75.

Stanic B, Katsuyama M, and Miller FJ Jr. An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. Arterioscler. Thromb. Vasc. Biol. 2010; 30:2234-41.

NOX1 Antibody: MOX1, NOH1, NOH-1, GP91-2, MOX1, NADPH oxidase 1, Mitogenic oxidase 1, NOX-1

ELISA, WB, IHC-P, IF

148536873

Liquid