NOX3 Antilichaam

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3) . It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4) .

50508

Q9HBY0

NP_056533

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

NOX3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

NOX3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOX3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

NOX3 antibody is human and mouse reactive. NOX3 is predicted to not cross-react with other NOX proteins.

NOX3

Cat. No. 10-401 - Human Kidney Tissue Slide

NADPH oxidase 3

Homo sapiens

Bedard K and Krause KH. The Nox family of ROS-generating NAPDH oxidases: physiology and pathophysiology. Physiol. Rev. 2007; 87:245-313.

Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-40.

Paffenholz R, Bergstrom RA, Pasutto F, et al. Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004; 18:486-91.

Mukherjea, Jajoo S, Sheehan K, et al. NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. Antioxidants and Redox Signaling 2011; 14:999-1010.

NAPDH oxidase 3, NOX-3, GP91-3, MOX2, MOX-2

ELISA, WB, IHC-P, IF

11136626

Liquid