NOX4 Antilichaam

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX4 is is expressed in multiple tissues and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS) (2,3) . Unlike other NOX proteins, NOX4 does not require cytosolic subunits and thus is constitutively active (4) . The function of NOX4 remains unclear as it plays both protective and deleterious roles in cellular metabolism.

50507

Q9NPH5

NP_058627

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

NOX4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

NOX4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NOX4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

NOX4 antibody is human, mouse, and rat reactive. At least four isoforms of NOX4 are known to exist. NOX4 is predicted to not cross-react with other NOX proteins.

NOX4

Cat. No. 10-901 - Human Spleen Tissue Slide

NADPH oxidase 4

Homo sapiens

Bedard K and Krause KH. The Nox family of ROS-generating NAPDH oxidases: physiology and pathophysiology. Physiol. Rev. 2007; 87:245-313.

Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-40.

Montezano AC, Burger D, Ceravolo GS, et al. Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clin. Sci. 2011; 120:131-41.

Martyn KD, Frederick LM, von Loehneysen K, et al. Functional analysis of Nox4 reveals unique characteristics compared to other NAPDH oxidases. Cell. Signal. 2006; 18:69-82.

NAPDH oxidase 4, NOX-4, RENOX, KOX, KOX-1

ELISA, WB, IHC-P, IF

8393843

Liquid