Noxa Antilichaam

Noxa Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.

58801

Q9JM54

NP_067426

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Noxa Antibody is immunoaffinity chromatography purified IgG.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

Noxa Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Noxa antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Pmaip1

Cat. No. 10-801 - Human Stomach Tissue Slide

Phorbol-12-myristate-13-acetate-induced protein 1

Homo sapiens

Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8.

Nakano K and Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 2001; 7:683-94.

Yu J, Zhang L, Hwang PM, et al. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 2001; 7:673-82.

Eferl R, Ricci R, Kenner L, et al. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 2003; 112:181-92.

Noxa Antibody: Noxa, Phorbol-12-myristate-13-acetate-induced protein 1

ELISA, WB, IHC-P, IF

10946832

Liquid