NP137
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
NP137 is a human IgG1 monoclonal antibody (mAb) targeting Netrin-1. NP137 inhibits the binding of netrin-1 to its receptor UNC5H2 (IC50: 0.5 nM). NP137 activates caspase 3 to induce apoptosis. NP137 can be used in solid tumors and hematologic malignancies research. Recommended isotype control: Human IgG1 kappa, Isotype Control.
12352203
Apoptosis
Apoptosis
Cancer-programmed cell death
Cancer
99.58
[NP137]
(144.60 kDa)
[1]Ducarouge B, et al. Preclinical characteristics of NP137, a first-in-class monoclonal antibody directed against netrin-1 and inducing dependence receptors-mediated cell death[J]. Cancer Research, 2015, 75 (15_Supplement) : 2921-2921.
Dry Ice
-80°C
http://file.medchemexpress.com/batch_PDF/HY-P991427/NP137-SDS-MedChemExpress.pdf
Inhibitory Antibodies
No Development Reported
Beschrijving
NP137 is a human IgG1 monoclonal antibody (mAb) targeting Netrin-1. NP137 inhibits the binding of netrin-1 to its receptor UNC5H2 (IC50: 0.5 nM). NP137 activate
Specificaties
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