NPM1 ALK Recombinant humaan actief eiwit Kinase

The NPM1-ALK protein contains the NPM1 oligomerization motif and the ALK catalytic domain, is constitutively activated through autophosphorylation, and mediates malignant cell transformation by activating downstream effectors including STAT3. NPM1 ALK Recombinant Human Active Protein Kinase is a recombinant NPM1 ALK protein that can be used to study NPM1 ALK-related functions[1].

12352211

Anaplastic lymphoma kinase (ALK)

Protein Tyrosine Kinase/RTK

Cancer

[NPM1ALKRecombinantHumanActiveProteinKinase]

[1]Zhang Q, et al. STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. Nat Med. 2007 Nov;13 (11) :1341-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-E70760/

Enzyme

No Development Reported