NPM1 Antilichaam (7H10B9]

Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM1 has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase .

4869

P06748

P06748

Human

Ni-NTA purified recombinant human NPM1 expressed in E. Coli strain BL21 (DE3) .

7H10B9

Unconjugated

Primary Antibodies

Other

Antibody is purified by protein A affinity chromatography.

Batch dependent

None

Blue Ice

NPM1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

NPM1

Nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Homo sapiens

Morris SW, et al. Science 1994 Mar 4; 263 (5151) :1281-4.

Yoneda-Kato N, et al. Oncogene. 1996 Jan 18;12 (2) :265-75.

Liu HT, Yung BY. Cancer Lett. 1999 Sep 20;144 (1) :45-54.

NPM, Nucleolar phosphoprotein B23, NPM, B23

ELISA, WB, IHC

114762

Liquid